An Origyn Solutions Portfolio Company

Reimagining urinary incontinence
at the source

1 in 2 women live with urinary incontinence; yet fewer than 1 in 3 ever seek treatment. Genevi treats the Urethra, the true cause, not just the symptom.

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1 in 2 women experience UIOnly 1 in 3 ever seek care78M U.S. women affected

Most women give up
and wear pads

One in two women experiences urinary incontinence (78 million in the U.S.) yet only one in three ever raises it with a doctor. Dismissed as just a normal part of aging, women deny it for years and quietly manage with pads, fluid restriction, bathroom mapping, and Kegels.

The treatment path that does exist is cumbersome, with suboptimal results: behavior modification and pelvic-floor training give way to drugs, injections, and surgery, and nearly all of it targets symptoms rather than cause. Most women give up along the way.

The scale of the
unmet need

0million

U.S. women live with urinary incontinence — one in two.

0%
Cannot live freely

of women with UI report they cannot exercise, laugh, or live without embarrassing leaks.

0in 3
Ever seek care

Only one in three women ever seeks advice from a doctor. Most manage alone, for years.

0%
Lower closure pressure

Urethral closure pressure is 42% lower in women with UI and is the leading predictive indicator of the condition.

0%
Muscle loss over time

Aging leads to a staggering loss of urethral muscle and nerve: up to 65% degradation over a lifetime.

Sources: Patel et al. 2022 · Melville et al. 2005 · DeLancey et al. 2008 · U. Michigan Pelvic Floor Research Group

Urinary incontinence is driven by urethral failure. Not pelvic floor support.

01

The Real Predictor

Urethral closure pressure, not pelvic floor support, is the strongest predictor of incontinence. Women with stress urinary incontinence have maximum urethral closure pressure roughly 42% lower than continent women (Delancey et al., J Urol 2008).

02

Where It Actually Breaks Down

The urethra itself loses muscle and nerve tissue with age. Roughly 65% of urethral striated muscle fiber is lost over time, alongside a parallel decline in nerve density. That breakdown, not a loss of pelvic support, tracks with the loss of closure pressure (Ashton-Miller & Delancey, 2007)

03

Why Today's Treatments Miss It

Pelvic floor strength looks nearly identical in continent and incontinent women. Kegels, pelvic floor PT, and slings all target support structures around the urethra, not the urethral muscle itself. Genevi treats the urethra directly.

Learn more about Genevi

For clinicians, partners, and women who want to follow Genevi's progress — start a conversation.

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An Origyn Solutions Portfolio CompanyUrinary Incontinence